Pharmacological blockade of memory reconsolidation in posttraumatic stress disorder: three negative psychophysiological studies.
Identifieur interne : 000385 ( Main/Exploration ); précédent : 000384; suivant : 000386Pharmacological blockade of memory reconsolidation in posttraumatic stress disorder: three negative psychophysiological studies.
Auteurs : Nellie E. Wood [États-Unis] ; Maria L. Rosasco [États-Unis] ; Alina M. Suris [États-Unis] ; Justin D. Spring [États-Unis] ; Marie-France Marin [États-Unis] ; Natasha B. Lasko [États-Unis] ; Jared M. Goetz [États-Unis] ; Avital M. Fischer [États-Unis] ; Scott P. Orr [États-Unis] ; Roger K. Pitman [États-Unis]Source :
- Psychiatry research [ 1872-7123 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Anciens combattants (psychologie), Antagonistes bêta-adrénergiques (pharmacologie), Antagonistes bêta-adrénergiques (usage thérapeutique), Femelle, Humains, Imagination (), Jeune adulte, Mifépristone (usage thérapeutique), Mâle, Méthode en double aveugle, Propranolol (pharmacologie), Propranolol (usage thérapeutique), Rappel mnésique (), Rythme cardiaque (), Récepteurs aux glucocorticoïdes (), Troubles de stress post-traumatique (psychologie), Troubles de stress post-traumatique (traitement médicamenteux), Troubles psychiques liés à la guerre (psychologie), Troubles psychiques liés à la guerre (traitement médicamenteux), Émotions (), Éveil ().
- MESH :
- pharmacologie : Antagonistes bêta-adrénergiques, Propranolol.
- psychologie : Anciens combattants, Troubles de stress post-traumatique, Troubles psychiques liés à la guerre.
- traitement médicamenteux : Troubles de stress post-traumatique, Troubles psychiques liés à la guerre.
- usage thérapeutique : Antagonistes bêta-adrénergiques, Mifépristone, Propranolol.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Imagination, Jeune adulte, Mâle, Méthode en double aveugle, Rappel mnésique, Rythme cardiaque, Récepteurs aux glucocorticoïdes, Émotions, Éveil.
English descriptors
- KwdEn :
- Adrenergic beta-Antagonists (pharmacology), Adrenergic beta-Antagonists (therapeutic use), Adult, Arousal (drug effects), Combat Disorders (drug therapy), Combat Disorders (psychology), Double-Blind Method, Emotions (drug effects), Female, Heart Rate (drug effects), Humans, Imagination (drug effects), Male, Mental Recall (drug effects), Middle Aged, Mifepristone (therapeutic use), Propranolol (pharmacology), Propranolol (therapeutic use), Receptors, Glucocorticoid (drug effects), Stress Disorders, Post-Traumatic (drug therapy), Stress Disorders, Post-Traumatic (psychology), Veterans (psychology), Young Adult.
- MESH :
- chemical , drug effects : Receptors, Glucocorticoid.
- chemical , pharmacology : Adrenergic beta-Antagonists, Propranolol.
- chemical , therapeutic use : Adrenergic beta-Antagonists, Mifepristone, Propranolol.
- drug effects : Arousal, Emotions, Heart Rate, Imagination, Mental Recall.
- drug therapy : Combat Disorders, Stress Disorders, Post-Traumatic.
- psychology : Combat Disorders, Stress Disorders, Post-Traumatic, Veterans.
- Adult, Double-Blind Method, Female, Humans, Male, Middle Aged, Young Adult.
Abstract
Posttraumatic stress disorder (PTSD) may involve over-consolidated emotional memories of the traumatic event. Reactivation (RP) can return a memory to an unstable state, from which it must be restabilized (reconsolidated) if it is to persist. Pharmacological agents administered while the memory is unstable have been shown to impair reconsolidation. The N-methyl-d-aspartate (NMDA) partial agonist d-cycloserine (DCS) may promote memory destabilization. In the three studies reported here, we investigated whether the β-adrenergic blocker propranolol or the glucocorticoid (GR) antagonist mifepristone, given at the time of traumatic memory reactivation, could reduce PTSD symptoms and physiological responding during subsequent traumatic imagery. Individuals with PTSD were randomized as follows: Study One: propranolol with memory reactivation (n=10) or without reactivation (n=8); Study Two: reactivation mifepristone (n=13), non-reactivation (NRP) mifepristone (n=15), or double placebo (PL) (n=15); Study Three: reactivation mifepristone plus d-cycloserine (n=16), or two placebos (n=15). Subjects underwent memory retrieval by describing their traumatic event. A week later they engaged in script-driven traumatic mental imagery, while heart rate (HR), skin conductance (SC), and facial electromyogram (EMG) responses were measured. There were no significant group differences in physiological responsivity or change in PTSD symptoms in any of the studies. These results do not support successful blockade of reconsolidation of traumatic memories in PTSD.
DOI: 10.1016/j.psychres.2014.09.005
PubMed: 25441015
Affiliations:
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Wood</name><affiliation wicri:level="2"><nlm:affiliation>Tufts University School of Medicine, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Tufts University School of Medicine, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Rosasco, Maria L" sort="Rosasco, Maria L" uniqKey="Rosasco M" first="Maria L" last="Rosasco">Maria L. Rosasco</name><affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Suris, Alina M" sort="Suris, Alina M" uniqKey="Suris A" first="Alina M" last="Suris">Alina M. Suris</name><affiliation wicri:level="2"><nlm:affiliation>VA North Texas Health Care System, and Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>VA North Texas Health Care System, and Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Spring, Justin D" sort="Spring, Justin D" uniqKey="Spring J" first="Justin D" last="Spring">Justin D. Spring</name><affiliation wicri:level="1"><nlm:affiliation>Columbia University College of Physicians and Surgeons, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Columbia University College of Physicians and Surgeons</wicri:regionArea></affiliation></author><author><name sortKey="Marin, Marie France" sort="Marin, Marie France" uniqKey="Marin M" first="Marie-France" last="Marin">Marie-France Marin</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 120 Second Ave, Charlestown, Boston, MA 02129, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 120 Second Ave, Charlestown, Boston, MA 02129</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Lasko, Natasha B" sort="Lasko, Natasha B" uniqKey="Lasko N" first="Natasha B" last="Lasko">Natasha B. Lasko</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 120 Second Ave, Charlestown, Boston, MA 02129, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 120 Second Ave, Charlestown, Boston, MA 02129</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Goetz, Jared M" sort="Goetz, Jared M" uniqKey="Goetz J" first="Jared M" last="Goetz">Jared M. Goetz</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 120 Second Ave, Charlestown, Boston, MA 02129, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 120 Second Ave, Charlestown, Boston, MA 02129</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Fischer, Avital M" sort="Fischer, Avital M" uniqKey="Fischer A" first="Avital M" last="Fischer">Avital M. Fischer</name><affiliation wicri:level="2"><nlm:affiliation>Boston University School of Medicine, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Boston University School of Medicine, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Orr, Scott P" sort="Orr, Scott P" uniqKey="Orr S" first="Scott P" last="Orr">Scott P. Orr</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 120 Second Ave, Charlestown, Boston, MA 02129, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 120 Second Ave, Charlestown, Boston, MA 02129</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Pitman, Roger K" sort="Pitman, Roger K" uniqKey="Pitman R" first="Roger K" last="Pitman">Roger K. Pitman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 120 Second Ave, Charlestown, Boston, MA 02129, USA. Electronic address: roger_pitman@hms.harvard.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 120 Second Ave, Charlestown, Boston, MA 02129</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><series><title level="j">Psychiatry research</title><idno type="eISSN">1872-7123</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenergic beta-Antagonists (pharmacology)</term><term>Adrenergic beta-Antagonists (therapeutic use)</term><term>Adult</term><term>Arousal (drug effects)</term><term>Combat Disorders (drug therapy)</term><term>Combat Disorders (psychology)</term><term>Double-Blind Method</term><term>Emotions (drug effects)</term><term>Female</term><term>Heart Rate (drug effects)</term><term>Humans</term><term>Imagination (drug effects)</term><term>Male</term><term>Mental Recall (drug effects)</term><term>Middle Aged</term><term>Mifepristone (therapeutic use)</term><term>Propranolol (pharmacology)</term><term>Propranolol (therapeutic use)</term><term>Receptors, Glucocorticoid (drug effects)</term><term>Stress Disorders, Post-Traumatic (drug therapy)</term><term>Stress Disorders, Post-Traumatic (psychology)</term><term>Veterans (psychology)</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Anciens combattants (psychologie)</term><term>Antagonistes bêta-adrénergiques (pharmacologie)</term><term>Antagonistes bêta-adrénergiques (usage thérapeutique)</term><term>Femelle</term><term>Humains</term><term>Imagination ()</term><term>Jeune adulte</term><term>Mifépristone (usage thérapeutique)</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Propranolol (pharmacologie)</term><term>Propranolol (usage thérapeutique)</term><term>Rappel mnésique ()</term><term>Rythme cardiaque ()</term><term>Récepteurs aux glucocorticoïdes ()</term><term>Troubles de stress post-traumatique (psychologie)</term><term>Troubles de stress post-traumatique (traitement médicamenteux)</term><term>Troubles psychiques liés à la guerre (psychologie)</term><term>Troubles psychiques liés à la guerre (traitement médicamenteux)</term><term>Émotions ()</term><term>Éveil ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Receptors, Glucocorticoid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Adrenergic beta-Antagonists</term><term>Propranolol</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Adrenergic beta-Antagonists</term><term>Mifepristone</term><term>Propranolol</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Arousal</term><term>Emotions</term><term>Heart Rate</term><term>Imagination</term><term>Mental Recall</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Combat Disorders</term><term>Stress Disorders, Post-Traumatic</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antagonistes bêta-adrénergiques</term><term>Propranolol</term></keywords><keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Anciens combattants</term><term>Troubles de stress post-traumatique</term><term>Troubles psychiques liés à la guerre</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Combat Disorders</term><term>Stress Disorders, Post-Traumatic</term><term>Veterans</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Troubles de stress post-traumatique</term><term>Troubles psychiques liés à la guerre</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antagonistes bêta-adrénergiques</term><term>Mifépristone</term><term>Propranolol</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Imagination</term><term>Jeune adulte</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Rappel mnésique</term><term>Rythme cardiaque</term><term>Récepteurs aux glucocorticoïdes</term><term>Émotions</term><term>Éveil</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Posttraumatic stress disorder (PTSD) may involve over-consolidated emotional memories of the traumatic event. Reactivation (RP) can return a memory to an unstable state, from which it must be restabilized (reconsolidated) if it is to persist. Pharmacological agents administered while the memory is unstable have been shown to impair reconsolidation. The N-methyl-d-aspartate (NMDA) partial agonist d-cycloserine (DCS) may promote memory destabilization. In the three studies reported here, we investigated whether the β-adrenergic blocker propranolol or the glucocorticoid (GR) antagonist mifepristone, given at the time of traumatic memory reactivation, could reduce PTSD symptoms and physiological responding during subsequent traumatic imagery. Individuals with PTSD were randomized as follows: Study One: propranolol with memory reactivation (n=10) or without reactivation (n=8); Study Two: reactivation mifepristone (n=13), non-reactivation (NRP) mifepristone (n=15), or double placebo (PL) (n=15); Study Three: reactivation mifepristone plus d-cycloserine (n=16), or two placebos (n=15). Subjects underwent memory retrieval by describing their traumatic event. A week later they engaged in script-driven traumatic mental imagery, while heart rate (HR), skin conductance (SC), and facial electromyogram (EMG) responses were measured. There were no significant group differences in physiological responsivity or change in PTSD symptoms in any of the studies. These results do not support successful blockade of reconsolidation of traumatic memories in PTSD.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li><li>Pennsylvanie</li><li>Texas</li></region></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Wood, Nellie E" sort="Wood, Nellie E" uniqKey="Wood N" first="Nellie E" last="Wood">Nellie E. Wood</name></region><name sortKey="Fischer, Avital M" sort="Fischer, Avital M" uniqKey="Fischer A" first="Avital M" last="Fischer">Avital M. Fischer</name><name sortKey="Goetz, Jared M" sort="Goetz, Jared M" uniqKey="Goetz J" first="Jared M" last="Goetz">Jared M. Goetz</name><name sortKey="Lasko, Natasha B" sort="Lasko, Natasha B" uniqKey="Lasko N" first="Natasha B" last="Lasko">Natasha B. Lasko</name><name sortKey="Marin, Marie France" sort="Marin, Marie France" uniqKey="Marin M" first="Marie-France" last="Marin">Marie-France Marin</name><name sortKey="Orr, Scott P" sort="Orr, Scott P" uniqKey="Orr S" first="Scott P" last="Orr">Scott P. Orr</name><name sortKey="Pitman, Roger K" sort="Pitman, Roger K" uniqKey="Pitman R" first="Roger K" last="Pitman">Roger K. Pitman</name><name sortKey="Rosasco, Maria L" sort="Rosasco, Maria L" uniqKey="Rosasco M" first="Maria L" last="Rosasco">Maria L. Rosasco</name><name sortKey="Spring, Justin D" sort="Spring, Justin D" uniqKey="Spring J" first="Justin D" last="Spring">Justin D. Spring</name><name sortKey="Suris, Alina M" sort="Suris, Alina M" uniqKey="Suris A" first="Alina M" last="Suris">Alina M. Suris</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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